Transplanted dopaminergic neurons develop PD pathologic changes: A second case report
Identifieur interne : 002559 ( Main/Exploration ); précédent : 002558; suivant : 002560Transplanted dopaminergic neurons develop PD pathologic changes: A second case report
Auteurs : Jeffrey H. Kordower [États-Unis] ; Yaping Chu [États-Unis] ; Robert A. Hauser [États-Unis] ; C. Warren Olanow [États-Unis] ; Thomas B. Freeman [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-12-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Brain (pathology), Case study, Cell Transplantation (physiology), Dopamine (metabolism), Dopaminergic neuron, Humans, Lewy body, Male, Nervous system diseases, Neurons (metabolism), Parkinson Disease (metabolism), Parkinson Disease (pathology), Parkinson Disease (surgery), Transplantation, Tyrosine 3-Monooxygenase (metabolism), Vesicular Monoamine Transport Proteins (metabolism), substantial nigra, transplantation.
- MESH :
- chemical , metabolism : Dopamine, Tyrosine 3-Monooxygenase, Vesicular Monoamine Transport Proteins.
- metabolism : Neurons, Parkinson Disease.
- pathology : Brain, Parkinson Disease.
- physiology : Cell Transplantation.
- surgery : Parkinson Disease.
- Adult, Humans, Male.
Abstract
This report describes pathological changes within the grafted neurons of another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long‐term time point, some displayed Lewy bodies as evidenced by alpha‐synuclein, ubiquitin, and thioflavin‐S staining. Additionally, there was a general loss of dopamine transporter‐immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD‐like pathology is seen in young grafted neurons when they survive long term. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22369
Affiliations:
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Le document en format XML
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